Population pharmacokinetics of olanzapine in children.

ABSTRACT:

Aims

The aim of this study was to evaluate the population pharmacokinetics (PopPK) of olanzapine in children and devise a model-informed paediatric dosing scheme.

Methods

The PopPK of olanzapine was characterized using opportunistically collected plasma samples from children receiving olanzapine per standard of care for any indication. A nonlinear mixed effect modelling approach was employed for model development using the software NONMEM (v7.4). Simulations from the developed PopPK model were used to devise a paediatric dosing scheme that targeted comparable plasma exposures to adolescents and adults.

Results

Forty-five participants contributed 83 plasma samples towards the analysis. The median (range) postnatal age and body weight of participants were 3.8 years (0.2

SUBMITTER: Maharaj AR 

PROVIDER: S-EPMC9008710 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature