β-micrustoxin (Mlx-9), a PLA₂ from Micrurus lemniscatus snake venom: biochemical characterization and anti-proliferative effect mediated by p53.

ABSTRACT:

Background

Endogenous phospholipases A₂ (PLA₂) play a fundamental role in inflammation, neurodegenerative diseases, apoptosis and cellular senescence. Neurotoxins with PLA₂ activity are found in snake venoms from the Elapidae and Viperidae families. The mechanism of action of these neurotoxins have been studied using hippocampal and cerebellar neuronal cultures showing [Ca²⁺]i increase, mitochondrial depolarization and cell death. Astrocytes are rarely used as a model, despite being modulators at the synapses and responsible for homeostasis and defense in the central nervous system. Preserving the cell division ability, they can be utilized to study the cell proliferation process. In the present work cultured astrocytes and glioblastoma c

SUBMITTER: Dos Santos NFT 

PROVIDER: S-EPMC9008913 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature