Jammed Micro-Flake Hydrogel for Four-Dimensional Living Cell Bioprinting.

ABSTRACT: 4D bioprinting is promising to build cell-laden constructs (bioconstructs) with complex geometries and functions for tissue/organ regeneration applications. The development of hydrogel-based 4D bioinks, especially those allowing living cell printing, with easy preparation, defined composition, and controlled physical properties is critically important for 4D bioprinting. Here, a single-component jammed micro-flake hydrogel (MFH) system with heterogeneous size distribution, which differs from the conventional granular microgel, has been developed as a new cell-laden bioink for 4D bioprinting. This jammed cytocompatible MFH features scalable production and straightforward composition with shear-thinning, shear-yielding, and rapid self-healing properties. As such, it can be smoothly printed i

SUBMITTER: Ding A 

PROVIDER: S-EPMC9012690 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature