Dataset Information

Response to neoadjuvant chemotherapy and survival in molecular subtypes of resectable gastric cancer: a post hoc analysis of the D1/D2 and CRITICS trials.

ABSTRACT:

Background

Epstein-Barr virus positivity (EBV+) and microsatellite instability (MSI-high) are positive prognostic factors for survival in resectable gastric cancer (GC). However, benefit of perioperative treatment in patients with MSI-high tumors remains topic of discussion. Here, we present the clinicopathological outcomes of patients with EBV+, MSI-high, and EBV-/MSS GCs who received either surgery only or perioperative treatment.

Methods

EBV and MSI status were determined on tumor samples collected from 447 patients treated with surgery only in the D1/D2 trial, and from 451 patients treated perioperatively in the CRITICS trial. Results were correlated to histopathological response, morphological tumor characteristics, and survival.

Results

In the D1/D2 trial, 5-year cancer-related survival was 65.2% in 47 patients with EBV+, 56.7% in 47 patients with MSI-high, and 47.6% in 353 patients with EBV-/MSS tumors. In the CRITICS trial, 5-year cancer-related survival was 69.8% in 25 patients with EBV+, 51.7% in 27 patients with MSI-high, and 38.6% in 402 patients with EBV-/MSS tumors. Interestingly, all three MSI-high tumors with moderate to complete histopathological response (3/27, 11.1%) had substantial mucinous differentiation. No EBV+ tumors had a mucinous phenotype. 115/402 (28.6%) of EBV-/MSS tumors had moderate to complete histopathological response, of which 23/115 (20.0%) had a mucinous phenotype.

Conclusions

In resectable GC, MSI-high had favorable outcome compared to EBV-/MSS, both in patients treated with surgery only, and in those treated with perioperative chemo(radio)therapy. Substantial histopathological response was restricted to mucinous MSI-high tumors. The mucinous phenotype might be a relevant parameter in future clinical trials for MSI-high patients.

SUBMITTER: Biesma HD

PROVIDER: S-EPMC9013342 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature

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Publications

Response to neoadjuvant chemotherapy and survival in molecular subtypes of resectable gastric cancer: a post hoc analysis of the D1/D2 and CRITICS trials.

Biesma Hedde D HD Soeratram Tanya T D TTD Sikorska Karolina K Caspers Irene A IA van Essen Hendrik F HF Egthuijsen Jacqueline M P JMP Mookhoek Aart A van Laarhoven Hanneke W M HWM van Berge Henegouwen Mark I MI Nordsmark Marianne M van der Peet Donald L DL Warmerdam Fabienne A R M FARM Geenen Maud M MM Loosveld Olaf J L OJL Portielje Johanneke E A JEA Los Maartje M Heideman Daniëlle A M DAM Meershoek-Klein Kranenbarg Elma E Hartgrink Henk H HH van Sandick Johanna J Verheij Marcel M van de Velde Cornelis J H CJH Cats Annemieke A Ylstra Bauke B van Grieken Nicole C T NCT

Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association 20220207 3

<h4>Background</h4>Epstein-Barr virus positivity (EBV+) and microsatellite instability (MSI-high) are positive prognostic factors for survival in resectable gastric cancer (GC). However, benefit of perioperative treatment in patients with MSI-high tumors remains topic of discussion. Here, we present the clinicopathological outcomes of patients with EBV+, MSI-high, and EBV-/MSS GCs who received either surgery only or perioperative treatment.<h4>Methods</h4>EBV and MSI status were determined on tu ...[more]

PMID: 35129727

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Dataset Information

Response to neoadjuvant chemotherapy and survival in molecular subtypes of resectable gastric cancer: a post hoc analysis of the D1/D2 and CRITICS trials.

Background

Methods

Results

Conclusions

Publications

Response to neoadjuvant chemotherapy and survival in molecular subtypes of resectable gastric cancer: a post hoc analysis of the D1/D2 and CRITICS trials.

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