Association between serum tumor necrosis factor-α and sarcopenia in liver cirrhosis.

ABSTRACT:

Background/aims

Sarcopenia is an independent prognostic factor of liver cirrhosis (LC). However, the association between LC-related systemic inflammation and sarcopenia is unclear.

Methods

Sprague-Dawley rats were treated with thioacetamide (TAA) or saline as a control. Rifaximin was administered to TAA-induced LC rats. Enzyme-linked immunosorbent assay was performed to measure inflammatory mediators in rat serum. RT-PCR was performed to measure the molecular expression in tissues. Hematoxylin and eosin (H&E) staining and immunohistochemistry were performed to investigate tissue pathology. Serum tumor necrosis factor-α levels, liver stiffness (LS), and the L3 skeletal muscle index (L3SMI) were measured in 60 patients with chronic liver disease.

Results

LC and sarcopen

SUBMITTER: Han JW 

PROVIDER: S-EPMC9013623 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature