Ontology highlight
ABSTRACT:
SUBMITTER: Yang Z
PROVIDER: S-EPMC9014299 | biostudies-literature | 2022
REPOSITORIES: biostudies-literature
Yang Zhijian Z Xu Wenzheng W Zhai Ranran R Li Ting T Ning Zheng Z Pawitan Yudi Y Shen Xia X
Frontiers in genetics 20220329
Integrating genome-wide association studies (GWAS) with transcriptomic data, human complex traits and diseases have been linked to relevant tissues and cell types using different methods. However, different results from these methods generated confusion while no gold standard is currently accepted, making it difficult to evaluate the discoveries. Here, applying three methods on the same data source, we estimated the sensitivity and specificity of these methods in the absence of a gold standard. ...[more]