Keratin 17 testing in pancreatic cancer needle aspiration biopsies predicts survival.

ABSTRACT:

Background

Although pancreatic ductal adenocarcinoma (PDAC) has one of the lowest 5-year survival rates of all cancers, differences in survival exist between patients with clinically identical characteristics. The authors previously demonstrated that keratin 17 (K17) expression in PDAC, measured by RNA sequencing or immunohistochemistry (IHC), is an independent negative prognostic biomarker. Only 20% of cases are candidates for surgical resection, but most patients are diagnosed by needle aspiration biopsy (NAB). The aims of this study were to determine whether there was a correlation in K17 scores detected in matched NABs and surgical resection tissue sections and whether K17 IHC in NAB cell block specimens could be used as a negative prognostic biomarker in PDAC.

Methods

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SUBMITTER: Roa-Pena L 

PROVIDER: S-EPMC9014629 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature