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AIDS patient with severe T cell depletion achieved control but not clearance of SARS-CoV-2 infection.

ABSTRACT: A late presenter AIDS patient with severe T cell depletion presented non-severe COVID-19 symptoms, with prolonged viral shedding. Our case report supports the hypothesis that an effective T cell response may be dispensable for the control of COVID-19 progression to severe forms, while it may be necessary for SARS-CoV-2 clearance.

SUBMITTER: Spinicci M

PROVIDER: S-EPMC9015404 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature

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AIDS patient with severe T cell depletion achieved control but not clearance of SARS-CoV-2 infection.

Spinicci Michele M Mazzoni Alessio A Borchi Beatrice B Graziani Lucia L Mazzetti Marcello M Bartalesi Filippo F Botta Annarita A Tilli Marta M Pieralli Filippo F Coppi Marco M Giovacchini Nicla N Colao Maria Grazia MG Saccardi Riccardo R Rossolini Gian Maria GM Annunziato Francesco F Bartoloni Alessandro A

European journal of immunology 20211204 2

A late presenter AIDS patient with severe T cell depletion presented non-severe COVID-19 symptoms, with prolonged viral shedding. Our case report supports the hypothesis that an effective T cell response may be dispensable for the control of COVID-19 progression to severe forms, while it may be necessary for SARS-CoV-2 clearance. ...[more]

PMID: 34822185

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