Annotating Spike Protein Polymorphic Amino Acids of Variants of SARS-CoV-2, Including Omicron.

ABSTRACT: The prolonged global spread and community transmission of severe acute respiratory syndrome virus 2 (SARS-CoV-2) has led to the emergence of variants and brought questions regarding disease severity and vaccine effectiveness. We conducted simple bioinformatics on the spike gene of a representative of each variant. The data show that a number of polymorphic amino acids are located mostly on the amino-terminal side of the S1/S2 cleavage site. The Omicron variant diverges from the others, with the highest number of amino acid substitutions, including the receptor-binding site (RBS), epitopes, S1/S2 cleavage site, fusion peptide, and heptad repeat 1. The current sharp global increase in the frequency of the Omicron genome constitutes evidence of its high community transmissibility. In conclusi

SUBMITTER: Mahardika GN 

PROVIDER: S-EPMC9017565 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature