Convergent Coding of Recent and Remote Fear Memory in the Basolateral Amygdala.

ABSTRACT:

Background

In both rodents and humans, the basolateral amygdala (BLA) is essential for encoding and retrieving conditioned fear memories. Although the BLA is a putative storage site for these memories, recent evidence suggests that they become independent of the BLA with the passage of time.

Methods

We systematically examined the role for the BLA in the retrieval of recent (1 day) and remote (2 weeks) fear memory using optogenetic, electrophysiological, and calcium imaging methods in male and female Long-Evans rats. Critically, we used a behavioral design that permits within-subjects comparison of recent and remote memory at the same time point; freezing behavior served as the index of learned fear.

Results

We found that BLA c-Fos expression was similar after the retr

SUBMITTER: Liu J 

PROVIDER: S-EPMC9018498 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature