Doxycycline decreases amyloidogenic light chain-induced autophagy in isolated primary cardiac myocytes.

ABSTRACT:

Background

Immunoglobulin light chain (AL) cardiac amyloidosis is characterized by extracellular deposition of amyloid fibrils in the heart and is potentially fatal. Untreated, it manifests clinically as heart failure with a precipitous decline and a median survival of <6 months. AL cardiac amyloidosis is associated with impaired extracellular matrix homeostasis in the heart with increased matrix metalloproteinase (MMP) levels. This commmunication provides novel insights into a potential role for doxycycline, a non-selective MMP inhibitor in AL cardiac amyloidosis.

Methods/results

Adult rat ventricular myocytes stimulated with AL (obtained from cardiac amyloidosis patients) increased MMP-2 and MMP-9 activities (P < .05); the expression of autophagy marker microtubule associa

SUBMITTER: Valero-Munoz M 

PROVIDER: S-EPMC9020138 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature