Increased functional connectivity between limbic brain areas in healthy individuals with high versus low sensitivity to cold pain: A resting state fMRI study.

ABSTRACT:

Background

The representation of variability in sensitivity to pain by differences in neural connectivity patterns and its association with psychological factors needs further investigation. This study assessed differences in resting-state functional connectivity (rsFC) and its association to cognitive-affective aspects of pain in two groups of healthy subjects with low versus high sensitivity to pain (LSP vs. HSP). We hypothesized that HSP will show stronger connectivity in brain regions involved in the affective-motivational processing of pain and that this higher connectivity would be related to negative affective and cognitive evaluations of pain.

Methods

Forty-eight healthy subjects were allocated to two groups according to their tolerability to cold stimulation (cold p

SUBMITTER: Grouper H 

PROVIDER: S-EPMC9020745 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature