Coronary flow reserve and cardiovascular outcomes: a systematic review and meta-analysis.

ABSTRACT:

Aims

This meta-analysis aims to quantify the association of reduced coronary flow with all-cause mortality and major adverse cardiovascular events (MACE) across a broad range of patient groups and pathologies.

Methods and results

We systematically identified all studies between 1 January 2000 and 1 August 2020, where coronary flow was measured and clinical outcomes were reported. The endpoints were all-cause mortality and MACE. Estimates of effect were calculated from published hazard ratios (HRs) using a random-effects model. Seventy-nine studies with a total of 59 740 subjects were included. Abnormal coronary flow reserve (CFR) was associated with a higher incidence of all-cause mortality [HR: 3.78, 95% confidence interval (CI): 2.39-5.97] and a higher incidence of MACE (H

SUBMITTER: Kelshiker MA 

PROVIDER: S-EPMC9020988 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature