Dataset Information

Metabolomic Markers for Predicting Preeclampsia in the First Trimester of Pregnancy: A Retrospective Study.

ABSTRACT: We sought to identify the characteristic metabolite profile of blood plasma samples obtained from patients with preeclampsia. Direct high-resolution mass spectrometry was used to analyze samples from 79 pregnant women, 34 of whom had preeclampsia. We performed a comparative analysis of the metabolite profiles and found that they differed between pregnant women with and without preeclampsia. Lipids and sugars were identified as components of the metabolite profile that are likely to be associated with the development of preeclampsia. While PE was established only in the third trimester, a set of metabolites specific for the third trimester, including 2-(acetylamino)-1,5-anhydro-2-deoxy-4-O-b-D-galactopyranosyl-D-arabino-Hex-1-enitol, N-Acetyl-D-glucosaminyldiphosphodolichol, Cer(d18:0/20:0), and allolithocholic acid, was already traced in the first trimester. These components are also likely involved in lipid metabolism disorders and the development of oxidative stress.

SUBMITTER: Ilgisonis EV

PROVIDER: S-EPMC9025490 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature

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Metabolomic Markers for Predicting Preeclampsia in the First Trimester of Pregnancy: A Retrospective Study.

Ilgisonis Ekaterina V EV Shalina Raisa R Kasum-Zade Nigyar N Burkova Kristina G KG Trifonova Oxana P OP Maslov Dmitry L DL Kaysheva Anna L AL Markin Sergey S SS

Molecules (Basel, Switzerland) 20220412 8

We sought to identify the characteristic metabolite profile of blood plasma samples obtained from patients with preeclampsia. Direct high-resolution mass spectrometry was used to analyze samples from 79 pregnant women, 34 of whom had preeclampsia. We performed a comparative analysis of the metabolite profiles and found that they differed between pregnant women with and without preeclampsia. Lipids and sugars were identified as components of the metabolite profile that are likely to be associated ...[more]

PMID: 35458675

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Project description:BackgroundTo investigate the relationship between serum renal function indicators and preeclampsia (PE) in pregnant women at second trimester of pregnancy, determine the optimal critical values of the above indicators, and further identify the independent risk factors of PE.MethodsWe assessed the renal function indicators in second trimesters of 137 pregnant women with PE and 137 normal pregnant women who delivered at Shijiazhuang Fourth Hospital between January 2020 to December 2022. Paired t-tests, paired Mann-Whitney U tests, and Chi-square tests were used to evaluate differences of clinical data between the two groups. Receiver operating characteristic (ROC) curves was employed to establish the optimal critical values of the above indicators. A 1:1 matched case-control logistic regression analysis was conducted to identify the independent risk factors for PE.ResultsThe levels of serum uric acid and the ratio of serum uric acid to serum creatinine were significantly higher in the PE group compared to the control (P < 0.001), while the serum creatinine levels were higher in control group (P = 0.002). The incidence of adverse maternal (P < 0.001) and neonatal outcomes (P < 0.001) in the PE group were higher than those in the control group. A ROC analysis based on the occurrence of PE showed that the levels of serum uric acid (P < 0.001), serum creatinine (P = 0.006) and the ratio of serum uric acid to serum creatinine (P < 0.001) were statistically significant. After adjusting for confounding factors, elevated serum uric acid (a OR = 1.012, 95% CI [1.005-1.019], P < 0.001) and an increased serum uric acid to serum creatinine ratio (a OR = 1.190, 95% CI [1.053-1.346], P = 0.005) were identified as independent risk factors for PE. There was no significant difference in renal function between maternal and newborn group in relation to the occurrence of adverse outcomes (P > 0.05 vs. all groups).ConclusionsThrough the analysis of renal function indicators in patients with PE in the second trimester of pregnancy and those in a normal control group, it is found that elevated serum uric acid and serum uric acid to serum creatinine ratio in PE individual may serve as indicative markers for the onset of PE. Targeting this subset of the population for monitoring and management during the second trimester could enhance the efficacy of medical interventions.

Project description:Although prior studies have shown that smoking reduces preeclampsia/eclampsia risk, the consequence of giving up this habit during pregnancy should be assessed. The aims of the current study were threefold: (i) describe maternal characteristics of women with preeclampsia/eclampsia; (ii) examine a possible association between the number of cigarettes smoked daily during pregnancy and the development of this affliction; and (iii) determine if first-trimester discontinuation of smoking during pregnancy influences the risk.A registry-based study was conducted using data from the Murmansk County Birth Registry (MCBR). It included women without pre-existing hypertension, who delivered a singleton infant during 2006-2011 and had attended the first antenatal visit before 12 week of gestation. We adjusted for potential confounders using logistic regression.The prevalence of preeclampsia/eclampsia was 8.3% (95%CI: 8.0-8.6). Preeclampsia/eclampsia associated with maternal age, education, marital status, parity, excessive weight gain and body mass index at the first antenatal visit. There was a dose-response relationship between the number of smoked cigarettes per day during pregnancy and the risk of preeclampsia/eclampsia (adjusted OR1-5 cig/day = 0.69 with 95%CI: 0.56-0.87; OR6-10 cig/day = 0.65 with 95%CI: 0.51-0.82; and OR≥11 cig/day = 0.49 with 95%CI: 0.30-0.81). There was no difference in this risk among women who smoked before and during pregnancy and those who did so before but not during pregnancy (adjusted OR = 1.10 with 95%CI: 0.91-1.32).Preeclampsia/eclampsia was associated with maternal age, education, marital status, parity, excessive weight gain, and body mass index at the first antenatal visit. There was a negative dose-response relationship between the number of smoked cigarettes per day during pregnancy and the odds of preeclampsia/eclampsia. However, women who gave up smoking during the first trimester of gestation had the same risk of preeclampsia/eclampsia as those who smoked while pregnant. Consequently, antenatal clinic specialists are advised to take these various observations into account when counselling women on smoking cessation during pregnancy.

Project description:PurposeDyslipidemia has been linked to adverse pregnancy outcomes in observational studies. This study aimed to explore how variations in lipid levels during the first trimester might influence early pregnancy loss (EPL).MethodsBlood samples from pregnant women were analyzed to examine the relationship between EPL and lipid metabolism using logistic regression and restricted cubic splines (RCS). Sensitivity analysis was conducted to verify the robustness of the results.ResultsElevated low-density lipoprotein cholesterol (LDL-C) and total cholesterol (TC) levels at most times of 4-9 weeks of gestation were associated with a higher risk of EPL, regardless of whether the control group was successful pregnancy or live birth. Specifically, taking the successful pregnancy group as a control example, increased EPL risks were observed in the highest quartile of plasma TC at 4 weeks (OR = 2.18, 95%: 1.14-4.21) and 7 weeks (OR = 4.30, 95%: 1.87-9.93) of pregnancy. Significant EPL risks were also noted in the third (Q3) and fourth (Q4) quartiles of LDL-C at 4 weeks (Q3, OR = 2.98, 95%: 1.47-6.08; Q4, OR = 2.66, 95%: 1.27-5.55) and 7 weeks (Q3, OR = 3.12, 95%: 1.44-6.73; Q4, OR = 5.17, 95%: 2.14-12.49). High TC levels (> 3.25-3.78 mmol/L) and high LDL-C levels (> 1.92-2.04 mmol/L) were linked to an increased risk of EPL compared to lower levels of TC (≤ 2.91-3.05 mmol/L) and LDL-C (≤ 1.64-1.75 mmol/L).RCS analysis further confirmed this finding that plasma TC and LDL-C levels at 4 and 7 weeks of gestation may have a linear relationship with the risk of EPL. By the way, triglyceride levels at 6 and 8 weeks of gestation were associated with a higher risk of EPL, whereas high-density lipoprotein cholesterol (HDL-C) levels at 5 and 9 weeks of gestation have a completely opposite relationship with EPL risk.ConclusionsElevated cholesterol levels during the first trimester are associated with an increased risk of early pregnancy loss, emphasizing the need for lipid monitoring during pregnancy and even before pregnancy.

Dataset Information

Metabolomic Markers for Predicting Preeclampsia in the First Trimester of Pregnancy: A Retrospective Study.

Publications

Metabolomic Markers for Predicting Preeclampsia in the First Trimester of Pregnancy: A Retrospective Study.

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