Crystal structure of SARS-CoV 3C-like protease with baicalein.

ABSTRACT: The 3C-like protease (M^pro, 3CL^pro) plays a key role in the replication process in coronaviruses (CoVs). The M^pro is an essential enzyme mediates CoVs replication and is a promising target for development of antiviral drugs. Until now, baicalein has been shown the specific activity for SARS-CoV M^pro in vitro experiments. In this study, we resolved the SARS-CoV M^pro with baicalein by X-ray diffraction at 2.25 Å (PDB code 7XAX), which provided a structural basis for the research and development of baicalein as an anti-CoVs drug.

SUBMITTER: Feng J 

PROVIDER: S-EPMC9027212 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature