Dataset Information

ERG and Behavioral CFF in Light-Damaged Albino Rats.

ABSTRACT: The full-field ERG is useful for index rod- or cone-mediated retinal function in rodent models of retinal degeneration. However, the relationship between the ERG response amplitudes and visually guided behavior, such as flicker detection, is not well understood. A comparison of ERG to behavioral responses in a light-damage model of retinal degeneration allows us to better understand the functional implications of electrophysiological changes. Flicker-ERG and behavioral responses to flicker were used to determine critical flicker frequency (CFF) under scotopic and photopic conditions before and up to 90 d after a 10-day period of low-intensity light damage. Dark- and light-adapted ERG flash responses were significantly reduced after light damage. The a-wave was permanently reduced, while the b-wave amplitude recovered over three weeks after light damage. There was a small, but significant dip in scotopic ERG CFF. Photopic behavioral CFF was slightly lower following light damage. The recovery of the b-wave amplitude and flicker sensitivity demonstrates the plasticity of retinal circuits following photopic injury.

SUBMITTER: Rubin GR

PROVIDER: S-EPMC9027716 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature

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Publications

ERG and Behavioral CFF in Light-Damaged Albino Rats.

Rubin Glen R GR Wen Yuquan Y Loop Michael S MS Kraft Timothy W TW

International journal of molecular sciences 20220408 8

The full-field ERG is useful for index rod- or cone-mediated retinal function in rodent models of retinal degeneration. However, the relationship between the ERG response amplitudes and visually guided behavior, such as flicker detection, is not well understood. A comparison of ERG to behavioral responses in a light-damage model of retinal degeneration allows us to better understand the functional implications of electrophysiological changes. Flicker-ERG and behavioral responses to flicker were ...[more]

PMID: 35456959

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Dataset Information

ERG and Behavioral CFF in Light-Damaged Albino Rats.

Publications

ERG and Behavioral CFF in Light-Damaged Albino Rats.

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