Dataset Information

Potential drug interactions in adults living in the Brazilian Amazon: A population-based case-control study, 2019.

ABSTRACT:

Background

Drug interactions are important causes of adverse events. Assessments of pharmacological interactions outside healthcare services settings are scarce.

Objective

To assess the frequency and factors associated with these potential interactions in adults living in Manaus, Amazonas, Brazil.

Methods

We conducted a case-control study in 2019 with residents who had taken two or more medicines two weeks before the interview. The cases involved people with potential drug interaction, according to Micromedex™, and adults without drug interactions formed the control group. The factors associated with interaction were identified by multivariate logistic regression.

Results

752 adults out of 2321 interviewed were using two or more medicines and were included. The prevalence of potential drug interactions was 30.2% (95% CI: 26.9; 33.5%). We identified 457 drug interactions, more frequently one interaction per person (49.7%), of major severity (61.9%), and with fair documentation (61.7%); three individuals were using contraindicated associations. Individuals aged 45-59 years (OR 1.88, 95% CI 1.03-3.42), using 3 or more drugs simultaneously (p-value<0.001), had higher chance of drug interactions.

Conclusion

Drug interaction was common in among adults living in Manaus, mostly of major severity. The odds of interaction increased with age and number of concomitantly medicines.

SUBMITTER: Biase TMMA

PROVIDER: S-EPMC9030716 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Potential drug interactions in adults living in the Brazilian Amazon: A population-based case-control study, 2019.

Biase Tayanny Margarida Menezes Almeida TMMA Silva Marcus Tolentino MT Galvao Tais Freire TF

Exploratory research in clinical and social pharmacy 20210812

<h4>Background</h4>Drug interactions are important causes of adverse events. Assessments of pharmacological interactions outside healthcare services settings are scarce.<h4>Objective</h4>To assess the frequency and factors associated with these potential interactions in adults living in Manaus, Amazonas, Brazil.<h4>Methods</h4>We conducted a case-control study in 2019 with residents who had taken two or more medicines two weeks before the interview. The cases involved people with potential drug ...[more]

PMID: 35480614

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Dataset Information

Potential drug interactions in adults living in the Brazilian Amazon: A population-based case-control study, 2019.

Background

Objective

Methods

Results

Conclusion

Publications

Potential drug interactions in adults living in the Brazilian Amazon: A population-based case-control study, 2019.

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