Dataset Information

Safety profile of SARS-CoV-2 vaccination in patients with antibody-mediated CNS disorders.

ABSTRACT:

Objectives

In this retrospective multicenter study, we evaluated the safety of SARS-CoV-2 vaccination in patients harboring autoantibodies targeting neuronal surface and/or synaptic antigens.

Methods

From eight Italian Neurology Units, we included patients with: a) serum and/or CSF positivity for specific neuronal autoantibodies; b) a compatible neurological syndrome; and c) available follow-up ≥6 weeks after vaccination with any of the approved SARS-CoV-2 vaccines. Demographics, clinical data, and information regarding previous SARS-CoV-2 infection and vaccination were collected. Disease relapses were considered "post-infectious" or "post-vaccination" when occurring within 6 weeks from infection/vaccination.

Results

We included 66 patients; 7/66 (11%) had a previous history of SARS-CoV-2 infection and 1/7 (14%) had post-infection relapses. BNT162b2-Pfizer-BioNTec was administered in 55 cases (83.3%) and mRNA-1273-Moderna in 11 (16.7%). The median number of doses administered per patient was 2 (1-3) and >50% of patients did not experience side effects. Five patients (8%) had post-vaccination relapses (seizure 3/5); 4/5 improved after immunotherapy, while one did not receive immunotherapy and worsened. Patients with post-vaccination relapses had higher disability scores at vaccination (p = 0.025), a trend favoring Leucine-rich glioma-inactivated protein 1 LGI1 glutamic acid decarboxylase 65 (GAD65) antibodies (p = 0.054) and shorter time from last relapse (p = 0.057).

Discussion

Our data support the safety of SARS-CoV-2 vaccines in patients with neurological disorders associated with antibodies to neuronal and synaptic antigens.

SUBMITTER: Dinoto A

PROVIDER: S-EPMC9035564 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature

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Publications

Safety profile of SARS-CoV-2 vaccination in patients with antibody-mediated CNS disorders.

Dinoto Alessandro A Gastaldi Matteo M Iorio Raffaele R Marini Sofia S Damato Valentina V Farina Antonio A Zoccarato Marco M Sechi Elia E Pinna Francesca F Maniscalco Giorgia Teresa GT Barnabei Ruggero R Zuliani Luigi L Ferrari Sergio S Mariotto Sara S

Multiple sclerosis and related disorders 20220425

<h4>Objectives</h4>In this retrospective multicenter study, we evaluated the safety of SARS-CoV-2 vaccination in patients harboring autoantibodies targeting neuronal surface and/or synaptic antigens.<h4>Methods</h4>From eight Italian Neurology Units, we included patients with: a) serum and/or CSF positivity for specific neuronal autoantibodies; b) a compatible neurological syndrome; and c) available follow-up ≥6 weeks after vaccination with any of the approved SARS-CoV-2 vaccines. Demographics, ...[more]

PMID: 35508101

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Dataset Information

Safety profile of SARS-CoV-2 vaccination in patients with antibody-mediated CNS disorders.

Objectives

Methods

Results

Discussion

Publications

Safety profile of SARS-CoV-2 vaccination in patients with antibody-mediated CNS disorders.

Similar Datasets

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