Neutrophil Extracellular Trap Density Increases With Increasing Histopathological Severity of Crohn's Disease.

ABSTRACT:

Background

Intestinal neutrophil recruitment is a characteristic feature of the earliest stages of inflammatory bowel disease (IBD). Neutrophil elastase (NE) and myeloperoxidase (MPO) mediate the formation of neutrophil extracellular traps (NETs); NETs produce the bactericidal oxidant hypochlorous acid (HOCl), causing host tissue damage when unregulated. The project aim was to investigate the relationship between NET formation and clinical IBD in humans.

Methods

Human intestinal biopsies were collected from Crohn's disease (CD) patients, endoscopically categorized as unaffected, transitional, or diseased, and assigned a histopathological score.

Results

A significant linear correlation was identified between pathological score and cell viability (TUNEL+). Immunohistoch

SUBMITTER: Schroder AL 

PROVIDER: S-EPMC9036391 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature