Multi-type childhood maltreatment exposure and substance use development from adolescence to early adulthood: A GxE study.

ABSTRACT:

Background

Childhood maltreatment types can co-occur and are associated with increased substance use during adolescence and early adulthood. There is also a strong genetic basis for substance use which interacts with environmental factors (e.g., childhood maltreatment) to influence substance use phenotype.

Objective

This research aimed to identify childhood maltreatment sub-groups based on type and chronicity, and their association with substance use change from adolescence to early adulthood, while accounting for the influence of substance use polygenic risk (i.e., genetic risk based on the combined effects of multiple genes).

Participants

We used a sample of unrelated European-origin Americans with genetic and childhood maltreatment data (n = 2,664) from the Nationa

SUBMITTER: Mishra AA 

PROVIDER: S-EPMC9036492 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature