Zika virus-induced TNF-α signaling dysregulates expression of neurologic genes associated with psychiatric disorders.

ABSTRACT:

Background

Zika virus (ZIKV) is an emerging flavivirus of global concern. ZIKV infection of the central nervous system has been linked to a variety of clinical syndromes, including microcephaly in fetuses and rare but serious neurologic disease in adults. However, the potential for ZIKV to influence brain physiology and host behavior following apparently mild or subclinical infection is less well understood. Furthermore, though deficits in cognitive function are well-documented after recovery from neuroinvasive viral infection, the potential impact of ZIKV on other host behavioral domains has not been thoroughly explored.

Methods

We used transcriptomic profiling, including unbiased gene ontology enrichment analysis, to assess the impact of ZIKV infection on gene expression i

SUBMITTER: Kung PL 

PROVIDER: S-EPMC9036774 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature