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Mesoporous MnFe₂O₄ magnetic nanoparticles as a peroxidase mimic for the colorimetric detection of urine glucose.

ABSTRACT: Mesoporous MnFe₂O₄ magnetic nanoparticles (mMnFe₂O₄ MNPs) were prepared with a one-step synthesis method and characterized to possess intrinsic peroxidase-like activity, and had obvious advantages over other peroxidase nanozymes in terms of high catalytic affinity, high stability, mono-dispersion, easy preparation, and quick separation. The mMnFe₂O₄ MNPs were used as a colorimetric sensor for indirect sensing of urine glucose based on the sensing principle that H₂O₂ can be produced from glucose oxidation catalyzed by glucose oxidase (GOx), and under the catalysis of the mMnFe₂O₄ MNPs nanozyme, H₂O₂ can oxidize 3,3',5,5'-tetramethylbenzidine (TMB) to produce a blue color in a few minutes. This sensor is simple, cheap, sensitive, and specific to glucose detection with a detection limit of 0.7 μM, suggesting its potential for on-site glucose detection.

SUBMITTER: Liu K

PROVIDER: S-EPMC9038020 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature

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Mesoporous MnFe2O4 magnetic nanoparticles as a peroxidase mimic for the colorimetric detection of urine glucose.

Liu Ke K Su Jiaxing J Liang Jiangong J Wu Yuan Y

RSC advances 20210823 45

Mesoporous MnFe2O4 magnetic nanoparticles (mMnFe2O4 MNPs) were prepared with a one-step synthesis method and characterized to possess intrinsic peroxidase-like activity, and had obvious advantages over other peroxidase nanozymes in terms of high catalytic affinity, high stability, mono-dispersion, easy preparation, and quick separation. The mMnFe2O4 MNPs were used as a colorimetric sensor for indirect sensing of urine glucose base ...[more]

PMID: 35480730

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