Substance use disorder is associated with alcohol-associated liver disease in patients with alcohol use disorder.

ABSTRACT:

Background and aims

Substance use disorder (SUD) commonly associates with alcohol use disorder (AUD), and certain substances have independently been shown to drive liver injury. In this work, we sought to determine if co-existing SUD in patients with AUD associated with the presence of alcohol-associated liver disease (ALD).

Methods

We performed a cross-sectional analysis using the Mass General Brigham Biobank to identify patients based on ICD-10 codes. We performed multivariate analyses accounting for a wide range of demographic and clinical variables to evaluate the association between SUD and ALD. We subsequently used the same method to evaluate the association between SUD and hepatic decompensation.

Results

We identified 2848 patients with a diagnosis of AUD, 9.0%

SUBMITTER: Vannier AGL 

PROVIDER: S-EPMC9038113 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature