Genetic Variants of <i>APOL1</i> Are Major Determinants of Kidney Failure in People of African Ancestry With HIV.

ABSTRACT:

Introduction

Variants of the APOL1 gene are associated with chronic kidney disease (CKD) in people of African ancestry, although evidence for their impact in people with HIV are sparse.

Methods

We conducted a cross-sectional study investigating the association between APOL1 renal risk alleles and kidney disease in people of African ancestry with HIV in the UK. The primary outcome was end-stage kidney disease (ESKD; estimated glomerular filtration rate [eGFR] of <15 ml/min per 1.73 m², chronic dialysis, or having received a kidney transplant). The secondary outcomes included renal impairment (eGFR <60 ml/min per 1.73 m²), albuminuria (albumin-to-creatinine ratio [ACR] >30 mg/mmol), and biopsy-proven HIV-associated nephropathy (HIVAN). Multi

SUBMITTER: Hung RKY 

PROVIDER: S-EPMC9039486 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature