Double-Spin Leukocyte-Rich Platelet-Rich Plasma Is Predominantly Lymphocyte Rich With Notable Concentrations of Other White Blood Cell Subtypes.

ABSTRACT:

Purpose

To comprehensively characterize a double-spin leukocyte-rich platelet-rich plasma (LR-PRP) formulation and to compare it with whole blood (WB) by quantitatively assessing platelet and WB cell subtype concentrations in each.

Methods

Prospective human ex vivo analysis with 12 healthy adult men with ages ranging from 25 to 31 was performed in a controlled laboratory setting. The main outcome measure was the leukocyte profile of human LR-PRP.

Results

In LR-PRP, lymphocytes were the predominant WB cell type (11.94 ± 2.97 × 10³ cells/μL) followed by neutrophils (3.72 ± 1.28 × 10³ cells/μL). The mean cumulative percentage of granulocytes was 23% ± 8% and agranulocytes was 77% ± 18%. There was a significant difference observed between granulocyte

SUBMITTER: Marathe A 

PROVIDER: S-EPMC9042761 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature