Ontology highlight
ABSTRACT:
SUBMITTER: Bose M
PROVIDER: S-EPMC9042795 | biostudies-literature | 2022 Apr
REPOSITORIES: biostudies-literature
Bose Mainak M Lampe Marko M Mahamid Julia J Ephrussi Anne A
Cell 20220323 8
Asymmetric localization of oskar ribonucleoprotein (RNP) granules to the oocyte posterior is crucial for abdominal patterning and germline formation in the Drosophila embryo. We show that oskar RNP granules in the oocyte are condensates with solid-like physical properties. Using purified oskar RNA and scaffold proteins Bruno and Hrp48, we confirm in vitro that oskar granules undergo a liquid-to-solid phase transition. Whereas the liquid phase allows RNA incorporation, the solid phase precludes i ...[more]