Isolation and biological activities of compounds from Rumex vesicarius L. and their use as a component of a synbiotic preparation.

ABSTRACT: The study evaluated prebiotic potential and the enzyme inhibition of extracts and isolated compounds of Rumex vesicarius (ruby dock), family Polygonaceae. Eight known compounds were identified in the roots of R. vesicarius. Extracts and compounds (1-8) increased the growth rate of Escherichia coli Nissle 1917 differentially compared to controls. The highest prebiotic index (PI) and activity score was recorded for EcN in the presence of compound 4, followed by, in descending order, petroleum ether, ethyl acetate, and total methanol extracts. The compounds and extracts reduced protease, α-amylase, and angiotensin-converting enzyme activities. This inhibitory activity was positively correlated with PI, P_score, µ_u, and Y_max</

SUBMITTER: Elbermawi A 

PROVIDER: S-EPMC9043391 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature