Folic acid and deoxycholic acid derivative modified Fe₃O₄ nanoparticles for efficient pH-dependent drug release and multi-targeting against liver cancer cells.

ABSTRACT: The novel nano-drug carrier (FDCA-FA-MNPs) was constructed by grafting formyl deoxycholic acid (FDCA) and folic acid (FA) on the surface of Fe₃O₄ magnetic nanoparticles (MNPs), possessing the advantages of superparamagnetism, good stability, low cytotoxicity and good blood compatibility. The hydrophobic anti-cancer drug doxorubicin hydrochloride (DOX) was successfully loaded onto FDCA-FA-MNPs through supramolecular interactions (hydrogen bond between FDCA and drug and hydrophobic interaction and π-π stacking between drug and drug). The drug loading amount and drug loading capacity were 509.1 mg g^-1 and 33.73 wt%, respectively. In addition, drug release had a pH responsive and controllable release performance, the release rate at pH 5.3 (45.6%) was four time

SUBMITTER: Wang X 

PROVIDER: S-EPMC9044570 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature