Minimizing adverse effects of Cerenkov radiation induced photodynamic therapy with transformable photosensitizer-loaded nanovesicles.

ABSTRACT:

Background

Photodynamic therapy (PDT) is a promising antitumor strategy with fewer adverse effects and higher selectivity than conventional therapies. Recently, a series of reports have suggested that PDT induced by Cerenkov radiation (CR) (CR-PDT) has deeper tissue penetration than traditional PDT; however, the strategy of coupling radionuclides with photosensitizers may cause severe side effects.

Methods

We designed tumor-targeting nanoparticles (¹³¹I-EM@ALA) by loading 5-aminolevulinic acid (ALA) into an ¹³¹I-labeled exosome mimetic (EM) to achieve combined antitumor therapy. In addition to playing a radiotherapeutic role, ¹³¹I served as an internal light source for the Cerenkov radiation (CR).

Results

The drug-loaded nanoparticles

SUBMITTER: Qian R 

PROVIDER: S-EPMC9044600 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature