Immune treatments for alcohol use disorder: A translational framework.

ABSTRACT: While the immune system is essential for survival, an excessive or prolonged inflammatory response, such as that resulting from sustained heavy alcohol use, can damage the host and contribute to psychiatric disorders. A growing body of literature indicates that the immune system plays a critical role in the development and maintenance of alcohol use disorder (AUD). As such, there is enthusiasm for treatments that can restore healthy levels of inflammation as a mechanism to reduce drinking and promote recovery. In this qualitative literature review, we provide a conceptual rationale for immune therapies and discuss progress in medications development for AUD focused on the immune system as a treatment target. This review is organized into sections based on primary signaling pathways targete

SUBMITTER: Meredith LR 

PROVIDER: S-EPMC9044974 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature