Association of Traumatic Brain Injury With and Without Loss of Consciousness With Neuropathologic Outcomes in Community-Dwelling Older Persons.

ABSTRACT:

Importance

A history of traumatic brain injury (TBI) has been considered a risk factor for Alzheimer dementia. However, the specific association of TBI, even without loss of consciousness (LOC), with pathologic findings that underlie Alzheimer dementia, including Alzheimer disease (AD), non-AD neurodegenerative, and vascular pathologic findings, remains unclear.

Objective

To examine the association between TBI with and without LOC and neuropathologic findings in community-based cohorts.

Design, setting, and participants

This cross-sectional analysis used neuropathologic data from 1689 participants from the Religious Orders Study, the Rush Memory and Aging Project, and the Minority Aging Research Study. These studies began enrollment in 1994, 1997, and 2004, respective

SUBMITTER: Agrawal S 

PROVIDER: S-EPMC9047640 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature