Newborn DNA methylation and asthma acquisition across adolescence and early adulthood.

ABSTRACT:

Background

Little is known about the association of newborn DNA methylation (DNAm) with asthma acquisition across adolescence and early adult life.

Objective

We aim to identify epigenetic biomarkers in newborns for asthma acquisition during adolescence or young adulthood.

Methods

The Isle of Wight Birth Cohort (IOWBC) (n = 1456) data at ages 10, 18 and 26 years were assessed. To screen cytosine-phosphate-guanine site (CpGs) potentially associated with asthma acquisition, at the genome scale, we examined differentially methylated regions (DMR) using dmrff R package and individual CpG sites using linear regression on such associations. For CpGs that passed screening, we examined their enrichment in biological pathways using their mapping genes and tested their associati

SUBMITTER: Li L 

PROVIDER: S-EPMC9050758 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature