Diffuse midline glioma H3K27M mutation in adult: A case report.

ABSTRACT:

Introduction

Diffuse midline glioma with H3 K27M mutation is a new tumor entity from 2016 which is highly aggressive and classified as a WHO Grade IV tumor regardless of histopathologic features. DMG is an aggressive tumor with a poor prognosis, predominating in children and rarely in adults. The clinicopathologic features in adults remain poorly characterized.

Case presentation

Herein we report a case of a 28-year-old female with diffuse midline glioma with pathology confirmation of histone H3 K27M mutation presenting predominately with left upper and lower limb weakness for 3 weeks followed by an event of loss of consciousness and suspicious mass in MRI Brain/CT Brain. It was confirmed by immunoreactive H3K27M with a score of 4+ in neoplastic cells, which revealed Diffuse

SUBMITTER: Bhattarai AM 

PROVIDER: S-EPMC9052283 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature