Model-based estimation of transmissibility and reinfection of SARS-CoV-2 P.1 variant.

ABSTRACT:

Background

The SARS-CoV-2 variant of concern (VOC) P.1 (Gamma variant) emerged in the Amazonas State, Brazil, in November 2020. The epidemiological consequences of its mutations have not been widely studied, despite detection of P.1 in 36 countries, with local transmission in at least 5 countries. A range of mutations are seen in P.1, ten of them in the spike protein. It shares mutations with VOCs previously detected in the United Kingdom (B.1.1.7, Alpha variant) and South Africa (B.1.351, Beta variant).

Methods

We estimated the transmissibility and reinfection of P.1 using a model-based approach, fitting data from the national health surveillance of hospitalized individuals and frequency of the P.1 variant in Manaus from December-2020 to February-2021.

Results

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SUBMITTER: Coutinho RM 

PROVIDER: S-EPMC9053218 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature