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Copper(ii)-catalyzed tandem cyclization for the synthesis of benzo[d][1,3]thiazin-2-yl phosphonates involving C-P and C-S bond formation.

ABSTRACT: A copper(ii)-catalyzed, high-efficiency and atom-economical synthesis of valuable organophosphorus compounds via tandem cyclization of o-alkynylphenyl isothiocyanates with phosphites is described. This protocol, having a good functional-group compatibility, provides a simple and direct pathway to organophosphorus heterocycles in good yields under mild conditions. The method could be efficiently scaled up to gram scale, thus providing a potential application of this cascade cyclization strategy in synthesis.

SUBMITTER: Liu Y 

PROVIDER: S-EPMC9056576 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature

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Copper(ii)-catalyzed tandem cyclization for the synthesis of benzo[<i>d</i>][1,3]thiazin-2-yl phosphonates involving C-P and C-S bond formation.

Liu Yang Y   Yao Shijie S   Wang Chaoli C   Zhang Yahui Y   Hao Wenyan W  

RSC advances 20200801 53

A copper(ii)-catalyzed, high-efficiency and atom-economical synthesis of valuable organophosphorus compounds <i>via</i> tandem cyclization of <i>o</i>-alkynylphenyl isothiocyanates with phosphites is described. This protocol, having a good functional-group compatibility, provides a simple and direct pathway to organophosphorus heterocycles in good yields under mild conditions. The method could be efficiently scaled up to gram scale, thus providing a potential application of this cascade cyclizat  ...[more]

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