A coumarin derivative-Cu²⁺ complex-based fluorescent chemosensor for detection of biothiols.

ABSTRACT: Herein, a novel fluorescent sensor has been developed for the detection of biothiols based on theoretical calculations of the stability constant of the complex between a Cu²⁺ ion and (E)-3-((2-(benzo[d]thiazol-2-yl)hydrazono)methyl)-7-(diethylamino) coumarin (BDC) as a fluorescent ligand. In this study, on the basis of density functional theory method, the Gibbs free energy of ligand-exchange reaction and the solvation model were carried out using thermodynamic cycles. The obtained results are in good agreement with the experimental data. The BDC-Cu²⁺ complex can be used as a fluorescent sensor for the detection of biothiols in the presence of non-thiol containing amino acids, with a detection limit for cysteine at 0.3 μM. Moreover, theoretical calculati

SUBMITTER: Hien NK 

PROVIDER: S-EPMC9057049 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature