Synthesis, study of antileishmanial and antitrypanosomal activity of imidazo pyridine fused triazole analogues.

ABSTRACT: Four groups, thirty-five compounds in total, of novel 1,2,3-triazole analogues of imidazo-[1,2-a]-pyridine-3-carboxamides were designed and synthesized using substituted pyridine, propargyl bromide, 2-azidoethyl 4-methyl benzenesulfonate and substituted acetylenes. These compounds were characterized using ¹H NMR, ¹³C NMR, LCMS and elemental analyses and a crystal structure was obtained for one of the significantly active compounds, 8f. All the synthesized and characterized compounds were screened in vitro for antileishmanial and antitrypanosomal activity against Leishmania major and Trypanosoma brucei parasites, respectively. Among the tested analogues, five compounds (8d, 8f, 8j, 10b and 10d) exhibited significant antileishmanial activity

SUBMITTER: Nandikolla A 

PROVIDER: S-EPMC9057266 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature