Cross coupling of benzylammonium salts with boronic acids using a well-defined N-heterocyclic carbene-palladium(ii) precatalyst.

ABSTRACT: N-heterocyclic carbene-palladium(ii)-catalyzed cross-coupling of benzylammonium salts with arylboronic acids for the synthesis of diarylmethane derivatives via C-N bond activation has been developed. Notably, in the presence of the easily prepared and bench-stable Pd-PEPPSI precatalyst, the Csp³-N bond activation of the benzylammonium salt even proceeded smoothly in isopropanol at room temperature.

SUBMITTER: Wang T 

PROVIDER: S-EPMC9060798 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature