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LANCL1 as the Key Immune Marker in Neuropathic Pain.


ABSTRACT:

Objective

This study is to explore key immune markers and changes of immune microenvironment in neuropathic pain (NeuP).

Method

The data sets of GSE145199 and GSE145226 in Gene Expression Omnibus (GEO) database was used to analyze, and the key immune markers were verified by GSE70006 and GSE91396, and the infiltration degree of immune cells in different samples were analyzed by CIBERSORT analysis package.

Results

In this study, we found a key immune marker, namely, LANCL1. Regulatory axis closely related to LANCL1 has also been found, namely, miR-6325/LANCL1 axis. In the immune infiltration analysis, we also found that the LANCL1 is positively correlated with T cells CD4 naïve (r = 0.880, p < 0.05).

Conclusion

In this study, we found that LANCL1 may be a protective factor for NeuP, and the miR-6325/LANCL1 axis may be involved in the occurrence and development of NeuP. Cascade reactions including mast cells, macrophages, and T cells may be an important reason for the aggravation of nerve damage.

SUBMITTER: Shi Y 

PROVIDER: S-EPMC9061068 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature

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Publications

LANCL1 as the Key Immune Marker in Neuropathic Pain.

Shi Yu Y   Zhang XueFei X   Fang Qian Q   Zhan Hongrui H   Wang Xianglong X   Huang Xiyan X   Fan Tao T   Liu Wei W   Wu Wen W  

Neural plasticity 20220425


<h4>Objective</h4>This study is to explore key immune markers and changes of immune microenvironment in neuropathic pain (NeuP).<h4>Method</h4>The data sets of GSE145199 and GSE145226 in Gene Expression Omnibus (GEO) database was used to analyze, and the key immune markers were verified by GSE70006 and GSE91396, and the infiltration degree of immune cells in different samples were analyzed by CIBERSORT analysis package.<h4>Results</h4>In this study, we found a key immune marker, namely, LANCL1.  ...[more]

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