LANCL1 as the Key Immune Marker in Neuropathic Pain.

ABSTRACT:

Objective

This study is to explore key immune markers and changes of immune microenvironment in neuropathic pain (NeuP).

Method

The data sets of GSE145199 and GSE145226 in Gene Expression Omnibus (GEO) database was used to analyze, and the key immune markers were verified by GSE70006 and GSE91396, and the infiltration degree of immune cells in different samples were analyzed by CIBERSORT analysis package.

Results

In this study, we found a key immune marker, namely, LANCL1. Regulatory axis closely related to LANCL1 has also been found, namely, miR-6325/LANCL1 axis. In the immune infiltration analysis, we also found that the LANCL1 is positively correlated with T cells CD4 naïve (r = 0.880, p < 0.05).

Conclusion

In this study, we found that LANCL1 m

SUBMITTER: Shi Y 

PROVIDER: S-EPMC9061068 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature