Molecular design principles towards exo-exclusive Diels-Alder reactions.

ABSTRACT: The exo selective Diels-Alder reactions, reported as special cases, usually involve catalytic reaction conditions and specific cyclic structural motifs on the diene and/or the dienophile. Here we report a systematic computational investigation on the substituent effect for simple, linear dienes and dienophiles towards exo control in Diels-Alder reactions under thermal conditions. Through detailed characterization of reaction pathways for Diels-Alder cycloadditions between linear dienes and dienophiles with various substituents, we summarize a set of design principles aiming for an optimal and nearly-exclusive exo selectivity. These results shall lead to valuable guidelines and more versatile strategies in organic synthesis that are in accordance with the principles of

SUBMITTER: Huang CJ 

PROVIDER: S-EPMC9061082 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature