Direct synthesis of 2-oxo-acetamidines from methyl ketones, aromatic amines and DMF via copper-catalyzed C(sp³)-H amidination.

ABSTRACT: A convenient method for the synthesis of 2-oxo-acetamidines from methyl ketones using aromatic amines and DMF as nitrogen sources is reported via copper-catalyzed C(sp³)-H amidination. Various methyl ketones react readily with aromatic amines and DMF, producing 2-oxo-acetamidines in yields of 47 to 92%. This protocol features the simultaneous formation of C-N and C[double bond, length as m-dash]N bonds using DMF and aromatic amines as two different nitrogen sources. It thus provides an efficient approach to construct acyclic amidines via three C(sp³)-H bond amidination. Based on the preliminary experiments, a plausible mechanism of this transformation is disclosed.

SUBMITTER: Xie D 

PROVIDER: S-EPMC9061129 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature