Dietary intervention improves health metrics and life expectancy of the genetically obese Titan mouse.

ABSTRACT: Suitable animal models are essential for translational research, especially in the case of complex, multifactorial conditions, such as obesity. The non-inbred mouse (Mus musculus) line Titan, also known as DU6, is one of the world's longest selection experiments for high body mass and was previously described as a model for metabolic healthy (benign) obesity. The present study further characterizes the geno- and phenotypes of this non-inbred mouse line and tests its suitability as an interventional obesity model. In contrast to previous findings, our data suggest that Titan mice are metabolically unhealthy obese and short-lived. Line-specific patterns of genetic invariability are in accordance with observed phenotypic traits. Titan mice also show modifications in the liver transcriptome, p

SUBMITTER: Muller-Eigner A 

PROVIDER: S-EPMC9065075 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature