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Microwave-assisted organic synthesis of nucleoside ProTide analogues.

ABSTRACT: A microwave enhanced synthesis of prodrug nucleotide (ProTide) analogues is presented. Comparison of conventional thermal heating reaction with microwave irradiation exemplifies the potential of the novel methodology herein presented for the selective 5'-phosphoramidate synthesis, without protection of the 3' position in the ribonucleoside.

SUBMITTER: Bordoni C 

PROVIDER: S-EPMC9065484 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature

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Microwave-assisted organic synthesis of nucleoside ProTide analogues.

Bordoni Cinzia C   Cima Cecilia Maria CM   Azzali Elisa E   Costantino Gabriele G   Brancale Andrea A  

RSC advances 20190627 35

A microwave enhanced synthesis of prodrug nucleotide (ProTide) analogues is presented. Comparison of conventional thermal heating reaction with microwave irradiation exemplifies the potential of the novel methodology herein presented for the selective 5'-phosphoramidate synthesis, without protection of the 3' position in the ribonucleoside. ...[more]

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