A Novel Multispecies Toxicokinetic Modeling Approach in Support of Chemical Risk Assessment.

ABSTRACT: Standardized laboratory tests with a limited number of model species are a key component of chemical risk assessments. These surrogate species cannot represent the entire diversity of native species, but there are practical and ethical objections against testing chemicals in a large variety of species. In previous research, we have developed a multispecies toxicokinetic model to extrapolate chemical bioconcentration across species by combining single-species physiologically based toxicokinetic (PBTK) models. This "top-down" approach was limited, however, by the availability of fully parameterized single-species models. Here, we present a "bottom-up" multispecies PBTK model based on available data from 69 freshwater fishes found in Canada. Monte Carlo-like simulations were performed using s

SUBMITTER: Mangold-Doring A 

PROVIDER: S-EPMC9066611 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature