New N-phenylacetamide-incorporated 1,2,3-triazoles: [Et₃NH][OAc]-mediated efficient synthesis and biological evaluation.

ABSTRACT: A facile, highly efficient, and greener method for the synthesis of new 1,4-disubstituted-1,2,3-triazoles was conducted using [Et₃NH][OAc] as a medium by the implementation of ultrasound irradiation via click chemistry, affording excellent yields. The present synthetic method exhibited numerous advantages such as mild reaction conditions, excellent product yields, minimal chemical waste, operational simplicity, shorter reaction time, and a wide range of substrate scope. The synthesized compounds were further evaluated for in vitro antifungal activity against five fungal strains, and some of the compounds displayed equivalent or greater potency than the standard drug. A molecular docking study against the modelled three-dimensional structure of cytochrome P450 lanos

SUBMITTER: Akolkar SV 

PROVIDER: S-EPMC9066712 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature