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New N-phenylacetamide-incorporated 1,2,3-triazoles: [Et3NH][OAc]-mediated efficient synthesis and biological evaluation.

ABSTRACT: A facile, highly efficient, and greener method for the synthesis of new 1,4-disubstituted-1,2,3-triazoles was conducted using [Et3NH][OAc] as a medium by the implementation of ultrasound irradiation via click chemistry, affording excellent yields. The present synthetic method exhibited numerous advantages such as mild reaction conditions, excellent product yields, minimal chemical waste, operational simplicity, shorter reaction time, and a wide range of substrate scope. The synthesized compounds were further evaluated for in vitro antifungal activity against five fungal strains, and some of the compounds displayed equivalent or greater potency than the standard drug. A molecular docking study against the modelled three-dimensional structure of cytochrome P450 lanosterol 14α-demethylase was also performed to understand the binding affinity and binding interactions of the enzyme. Furthermore, the synthesized compounds were evaluated for DPPH radical scavenging activity and antitubercular activity against Mycobacterium tuberculosis H37Rv strain.

SUBMITTER: Akolkar SV 

PROVIDER: S-EPMC9066712 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature

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New <i>N</i>-phenylacetamide-incorporated 1,2,3-triazoles: [Et<sub>3</sub>NH][OAc]-mediated efficient synthesis and biological evaluation.

Akolkar Satish V SV   Nagargoje Amol A AA   Krishna Vagolu S VS   Sriram Dharmarajan D   Sangshetti Jaiprakash N JN   Damale Manoj M   Shingate Bapurao B BB  

RSC advances 20190718 38

A facile, highly efficient, and greener method for the synthesis of new 1,4-disubstituted-1,2,3-triazoles was conducted using [Et<sub>3</sub>NH][OAc] as a medium by the implementation of ultrasound irradiation <i>via</i> click chemistry, affording excellent yields. The present synthetic method exhibited numerous advantages such as mild reaction conditions, excellent product yields, minimal chemical waste, operational simplicity, shorter reaction time, and a wide range of substrate scope. The syn  ...[more]

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