SCAR: The high-prevalence antigen 013.008 in the Scianna blood group system.

ABSTRACT:

Background

The Scianna (SC) blood group system comprises seven antigens. They reside on the erythroblast membrane-associated glycoprotein (ERMAP). The ERMAP and RHCE genes are juxtaposed to each other on chromosome 1. We report a novel SC antigen.

Study design and methods

Blood samples came from a patient and his two sisters in Saudi Arabia. To investigate the antibody specificity we used the column agglutination technique and soluble recombinant ERMAP protein. The significance of anti-SCAR was evaluated by the transfusion history and a monocyte monolayer assay. We determined the genomic sequence of ERMAP and RHCE genes.

Results

The patient's serum showed an antibody of titer 8 against a high-prevalence antigen. The soluble recombinant ERMAP protein inhibited the anti

SUBMITTER: Srivastava K 

PROVIDER: S-EPMC9067365 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature