Plasma Proteomics of COVID-19-Associated Cardiovascular Complications: Implications for Pathophysiology and Therapeutics.
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ABSTRACT:
SUBMITTER: Roh JD
PROVIDER: S-EPMC9067411 | biostudies-literature | 2022 May
REPOSITORIES: biostudies-literature
Publications
Plasma Proteomics of COVID-19-Associated Cardiovascular Complications: Implications for Pathophysiology and Therapeutics.
Roh Jason D JD Kitchen Robert R RR Guseh J Sawalla JS McNeill Jenna N JN Aid Malika M Martinot Amanda J AJ Yu Andy A Platt Colin C Rhee James J Weber Brittany B Trager Lena E LE Hastings Margaret H MH Ducat Sarah S Xia Peng P Castro Claire C Singh Abhilasha A Atlason Bjarni B Churchill Timothy W TW Di Carli Marcelo F MF Ellinor Patrick T PT Barouch Dan H DH Ho Jennifer E JE Rosenzweig Anthony A
JACC. Basic to translational science 20220504 5
To gain insights into the mechanisms driving cardiovascular complications in COVID-19, we performed a case-control plasma proteomics study in COVID-19 patients. Our results identify the senescence-associated secretory phenotype, a marker of biological aging, as the dominant process associated with disease severity and cardiac involvement. FSTL3, an indicator of senescence-promoting Activin/TGFβ signaling, and ADAMTS13, the von Willebrand Factor-cleaving protease whose loss-of-function causes mic ...[more]
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