Dataset Information

Patients dispensed medications with actionable pharmacogenomic biomarkers: rates and characteristics.

ABSTRACT:

Purpose

Pharmacogenomic biomarkers are increasingly listed on medication labels and authoritative guidelines but pharmacogenomic-guided prescribing is not yet common. Our objective was to assess the potential for incorporating knowledge of patients' genomic characteristics into prescribing practices.

Methods

We performed a retrospective analysis of claims data for 2,096,971 beneficiaries with pharmacy coverage from a national, commercial health insurance plan between January 2017 and December 2019. Children between 0 and 17 years comprised 21% of the cohort. Adults were age 18 to 64. Medications with actionable pharmacogenomic biomarkers (MAPBs) were identified using public information from the US Food and Drug Administration (FDA), Clinical Pharmacogenomics Implementation Consortium (CPIC), and PharmGKB.

Results

MAPBs were dispensed to 63% of the adults and 29% of the children in the cohort. Most frequently dispensed were ibuprofen, ondansetron, codeine, and oxycodone. Most common were medications with CYP2D6, G6PD, or CYPC19 pharmacogenomic biomarkers. Ten percent of the cohort were codispensed more than one MAPB for at least 30 days.

Conclusion

The number of people who might benefit from pharmacogenomic-guided prescribing is substantial. Future work should address obstacles to integrating genomic data into prescriber workflows, complex factors contributing to the magnitude of benefit, and the clinical availability of reliable on-demand or pre-emptive pharmacogenomic testing.

SUBMITTER: Liu D

PROVIDER: S-EPMC9067543 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Patients dispensed medications with actionable pharmacogenomic biomarkers: rates and characteristics.

Liu Dianbo D Olson Karen L KL Manzi Shannon F SF Mandl Kenneth D KD

Genetics in medicine : official journal of the American College of Medical Genetics 20210108 4

<h4>Purpose</h4>Pharmacogenomic biomarkers are increasingly listed on medication labels and authoritative guidelines but pharmacogenomic-guided prescribing is not yet common. Our objective was to assess the potential for incorporating knowledge of patients' genomic characteristics into prescribing practices.<h4>Methods</h4>We performed a retrospective analysis of claims data for 2,096,971 beneficiaries with pharmacy coverage from a national, commercial health insurance plan between January 2017 ...[more]

PMID: 33420348

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Dataset Information

Patients dispensed medications with actionable pharmacogenomic biomarkers: rates and characteristics.

Purpose

Methods

Results

Conclusion

Publications

Patients dispensed medications with actionable pharmacogenomic biomarkers: rates and characteristics.

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