Genetic background influences survival of infections with Salmonella enterica serovar Typhimurium in the Collaborative Cross.

ABSTRACT: Salmonella infections typically cause self-limiting gastroenteritis, but in some individuals these bacteria can spread systemically and cause disseminated disease. Salmonella Typhimurium (STm), which causes severe systemic disease in most inbred mice, has been used as a model for disseminated disease. To screen for new infection phenotypes across a range of host genetics, we orally infected 32 Collaborative Cross (CC) mouse strains with STm and monitored their disease progression for seven days by telemetry. Our data revealed a broad range of phenotypes across CC strains in many parameters including survival, bacterial colonization, tissue damage, complete blood counts (CBC), and serum cytokines. Eighteen CC strains survived to day 7, while fourteen susceptible strains succumbed to infecti

SUBMITTER: Scoggin K 

PROVIDER: S-EPMC9067680 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature