Brain-Based Biotypes of Psychiatric Vulnerability in the Acute Aftermath of Trauma.

ABSTRACT:

Objective

Major negative life events, such as trauma exposure, can play a key role in igniting or exacerbating psychopathology. However, few disorders are diagnosed with respect to precipitating events, and the role of these events in the unfolding of new psychopathology is not well understood. The authors conducted a multisite transdiagnostic longitudinal study of trauma exposure and related mental health outcomes to identify neurobiological predictors of risk, resilience, and different symptom presentations.

Methods

A total of 146 participants (discovery cohort: N=69; internal replication cohort: N=77) were recruited from emergency departments within 72 hours of a trauma and followed for the next 6 months with a survey, MRI, and physiological assessments.

Results

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SUBMITTER: Stevens JS 

PROVIDER: S-EPMC9069566 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature